Where bold science meets an obesity epidemic.

Our Approach

Obesity can be treated by decreasing calorie consumption and increasing calorie expenditure. However, when weight loss is driven primarily through calorie restriction, the body’s slowing resting metabolic rate, metabolic adaptation, can make sustained weight loss exceedingly difficult while also depriving the body of vital nutrients needed to maintain muscle mass and healthy body composition. At Adipo, we are developing a unique potential solution to these weight loss challenges by designing a treatment that focuses on energy expenditure, converting energy-storing white fat into metabolically beneficial, energy-burning brown fat using cutting-edge technology in the form of Notch-inhibiting nanoparticles. In animal studies, our approach leads to weight loss and improved blood glucose and lipid control with no change in calorie intake.