Imagine being able to transform energy-storing white fat into energy-burning brown fat. That’s the concept behind a first-in-class therapy that could soon treat obesity and type 2 diabetes. Adipo Therapeutics, an Indiana biotechnology company, is developing polymer-based, Notch-inhibiting nanoparticles that are injected directly into adipose (fat) tissue to induce browning, or white-to-beige adipocyte transformation.
The goal? Reducing weight and restoring metabolic balance for millions of people living with diabetes.
Our vision is to transform the treatment of people with Type 2 diabetes mellitus (T2DM). T2DM is a complex metabolic disorder characterized by high blood sugar, central obesity, high blood pressure, and high cholesterol, leading to an increased risk of complications and reduced life expectancy. While current treatments focus on increasing exercise, decreasing food intake, and increasing insulin, Adipo believes there is another option. Transformation of adipose tissue through browning has the potential to use the body’s own physiology to raise energy expenditure, reduce adiposity, and improve insulin resistance.
Adipo Therapeutics is developing an innovative technology platform of localized, polymer-based nanoparticulate delivery of Notch inhibitors to induce adipocyte browning in specific white fat depots. Once enough adipocyte transformation has occurred, the physiological effects resulting from local browning of adipose tissue will become systemic and drive greater energy expenditure and improved insulin sensitivity. Adipo’s innovative therapy combines the recent discovery of the role played by Notch signaling in adipocyte browning, with advances in polymer-based drug delivery to minimize the risk of systemic toxicity. Adipo’s treatment offers the potential of a unique value proposition for the treatment of type 2 diabetes, providing sustainable weight loss, improved glucose homeostasis and systemic metabolism, with minimized off-target side effects.Watch the Video
Adipo’s treatment offers the potential of a unique treatment for type 2 diabetes. Localized drug delivery that transforms the body’s own fat to burn energy and improve insulin resistance, resulting in sustained weight loss and blood glucose control.